Sarah Gagliano Taliun

Notre groupe utilise des approches computationnelles et bio-informatiques à la fine pointe de la technologie pour mieux comprendre les facteurs génétiques qui contribuent aux traits complexes et aux maladies courantes chez les êtres humains, y compris les maladies neurodégénératives.

American Society of Human Genetics

International Genetic Epidemiology Society

• 24-05-2021 Dre Sarah Gagliano Taliun : la génétique au service du cœur

Publications sélectionnées/Selected Publications
* Co-first authors/Co-premiers(ières) auteurs/autrices   † Co-senior authors/Co-sénior(e)s auteurs/autrices  ___ Membre de mon groupe de recherche/Member of my research group

F. Lona-Durazo, K. Omachi, D. Fermin, F. Eichinger, J.P. Troost, M.H. Lin, I.R. Dinsmore, T. Mirshahi, A.R. Chang, J.H. Miner, A.D. Paterson, M. Barua, S.A. Gagliano Taliun (2024) Association of Genetically Predicted Skipping of COL4A4 Exon 27 with Hematuria and Albuminuria. Journal of the American Society of Nephrology. PMID: 39190490

R. Diany, S.A. Gagliano Taliun (2024) Systematic review and phenome-wide scans of genetic associations with vascular cognitive impairment. Advanced Biology.  e2300692. PMID: 38935518

N. Neale*, F. Lona-Durazo*, M. Ryten†, S.A. Gagliano Taliun† (2024) Leveraging sex-genetic interactions to understand brain disorders: recent advances and current gaps. Brain Communications.  6(3):fcae192. PMID: 38894947

J. Bellavance*, L. Wang*, S.A. Gagliano Taliun (2024) Eight quick tips for including chromosome X in genome-wide association studies. PLoS Computational Biology. 20(6):e1012160. PMID: 38843110 

S.A. Gagliano Taliun, I.R. Dinsmore, T. Mirshahi, A.R. Chang, A.D. Paterson, M. Barua (2023) GWAS for the composite traits of hematuria and albuminuria. Scientific Reports. 13:18084. PMID: 37872228

Q. Ye, S.A. Gagliano Taliun (2023) Genetically predicted waist to hip circumference ratio and coronary artery disease: a sex-specific Mendelian randomization study. HGG Advances. https://doi.org/10.1016/j.xhgg.2023.100230. 4:100230. PMID: 37663544

F. Lona-Durazo, R.H. Reynolds, S.W. Scholz, M. Ryten, S.A. Gagliano Taliun (2023) Regional genetic correlations highlight relationships between neurodegenerative diseases and the immune system. Communications Biology. 6:729. PMID: 37454237

M. Shoaib, Q. Ye, H. IglayReger, M. Boehnke, C.F. Burant, S.A. Soleimanpour, S.A. Gagliano Taliun (2023) Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes. Genetic Epidmiology. 47, 303-313. 10.1002/gepi.22521. PMID: 6821788

Y. Zhao & S.A. Gagliano Taliun (2022) Lipid-lowering drug targets and Parkinson's disease: A sex-specific Mendelian randomization study. Front Neurol. 13:940118. PMID: 36119674

T.N. Kelly*, X. Sun*, K.Y. Ye*, M.R. Brown*, S.A. Gagliano Taliun*, J.N. Hellwge*, X. Mi*, J.A. Brody* […] ~100 middle authors […] T.L. Edwards, G.R. Abecasis, X. Zhu, D. Levy, D.K. Arnett, A.C. Morrison. (2022) Insights from a Large-Scale Whole Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension. Hypertension. PMID: 35652341 

S.A. Gagliano Taliun & D.M. Evans. (2021) Ten simple rules for conducting a Mendelian randomization study. PLoS Computational Biology. 17(8): e1009238. PMID: 34383747

D. Taliun*, D.N. Harris*, M.D. Kessler*, J. Carlson*, Z.A. Szpiech*, R. Torres*, S.A. Gagliano Taliun*, A. Corvelo*, [...] ~100 middle authors [...], C.C. Laurie, C.E. Jaquish, R.D. Hernandez, T.D. O'Connor, G.R. Abecasis. (2021) Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 590:290-299. PMID: 33568819

S.A. Gagliano Taliun*, P. VandeHaar*, A.P. Boughton, R.P. Welch, D. Taliun, E.M. Schmidt, W. Zhou, J.B. Nielsen, C.J. Willer, S. Lee, L.G. Fritsche, M. Boehnke, G.R. Abecasis (2020) Exploring and visualizing large-scale genetic associations using PheWeb. Nature Genetics. 52:550–552. PMID: 32504056

W. Zhou*, Z. Zhao*, J.B. Nielsen, L.G. Fritsche, J. LeFaive, S.A. Gagliano Taliun, W. Bi, M.J. Daly, B.M. Neale, K. Hveem, G.R. Abecasis, C.J. Willer, S. Lee. (2020) Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts. Nature Genetics. 52:634–639. PMID: 32424355

R.H. Reynolds, J. Hardy, M. Ryten†, S.A. Gagliano Taliun† (2019) Informing disease modelling with brain-relevant functional genomic annotations. Brain. 0:1-19. PMID: 31603214

D. Dutta, S.A. Gagliano Taliun, J. Weinstock, M. Zawistowski, C. Sidore, F. Cucca, D. Schlessinger, G. Abecasis, C. Brummett, S. Lee. (2019) Meta-MultiSKAT: Multiple phenotype meta-analysis for region-based association test. Genetic Epidemiology. 43(7):800-814. PMID: 31433078

R.H. Reynolds, J.A. Botía, M.A. Nalls, International Parkinson’s Disease Genomics Consortium (IPDGC), J. Hardy, S.A. Gagliano Taliun†, M. Ryten† (2019) Moving beyond neurons: the role of cell type-specific gene regulation in Parkinson’s disease heritability. 5:6. NPJ Parkinsons Disease. PMID: 31016231

S.A. Gagliano, S. Sengupta, C. Sidore, A. Maschio, F. Cucca, D. Schlessinger, G.R Abecasis (2018) Relative impact of indels versus SNPs on complex disease. Genetic Epidemiology. 43(1):112-117. PMID: 30565766

W. Zhou, J.B. Nielsen, L.G. Fritsche, R. Dey, M.B. Elvestad, B.N. Wolford, J. LeFaive, P. VandeHaar, S.A. Gagliano, A. Gifford, L.A. Bastarache, W-Q. Wei, J.C. Denny, M. Lin, K. Hveem, H.M. Kang, G.R. Abecasis, C.J. Willer, S. Lee (2018) Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. Nature Genetics. 50(9):1335-1341. PMID: 30104761

S.A. Gagliano, J. G. Pouget, J. Hardy, J. Knight, M.R. Barnes, M. Ryten, M.E. Weale (2016) Genomics implicates adaptive and innate immunity in Alzheimer’s and Parkinson’s. Annals of Clinical and Translational Neurology. 3(12):924-933. PMID: 28097204

S.A. Gagliano, C. Ptak, D.Y.F. Mak, M. Shamsi, G. Oh, J. Knight, P.C. Boutros, A. Petronis (2016) Allele-skewed DNA modification in the brain: relevance to schizophrenia GWAS. American Journal of Human Genetics. 98(5):956-962. PMID: 27087318