Shady Rahayel

Étudier le développement de la démence à corps de Lewy par le sommeil et l'imagerie computationnelle
Professeur sous octroi adjoint
Faculté de médecine - Département de médecine

Disciplines

  • Neuroradiologie
  • Neurologie
  • Anatomie
  • Gériatrie
  • Psychiatrie

Présence sur le Web

Expertise de recherche

Notre groupe utilise les dernières avancées en imagerie cérébrale et en neurosciences computationnelles pour caractériser les mécanismes pathophysiologiques qui mènent au développement de la démence à corps de Lewy et de la maladie de Parkinson, identifier des marqueurs prédictifs de ce développement et développer des traitements préventifs pour ces conditions. Nous nous intéressons particulièrement à un trouble du sommeil appelé trouble comportemental en sommeil paradoxal isolé.

Affiliations de recherche UdeM

Formations

2023 - Stage postdoctoral - Neurosciences
Université McGill (Canada)
2020 - Stage postdoctoral - Médecine nucléaire
Institut universitaire de gériatrie de Montréal (Canada)
2019 - PsyD PhD - Psychologie
Université du Québec à Montréal (Canada)

Pour en savoir plus

Publications

Filiatrault M, Ayral V, Tremblay C, Haddad C, Daneault V, Pastor-Bernier A, Gagnon JF, Postuma RB, Dušek P, Mareček S, Varga Z, Klein JC, Hu MT, Arnulf I, Dodet P, Vidailhet M, Corvol JC, Lehéricy S; ICEBERG Study Group; Lewis S, Matar E, Ehgoetz Martens KA, Churchill L, Borghammer P, Knudsen K, Hansen AK, Arnaldi D, Orso B, Mattioli P, Roccatagliata L, RAHAYEL S. Estrogen-related receptor gene expression associates with sex differences in cortical atrophy in isolated REM sleep behavior disorder. Nat Commun. 2025 Oct 10;16(1):9016. doi: 10.1038/s41467-025-63829-w. PMID: 41073384; PMCID: PMC12514017.

Haddad C, Daneault V, Ayral V, Filiatrault M, Pastor-Bernier A, Tremblay C, Boré A, Descoteaux M, Vo A, Gagnon JF, Postuma RB, Dusek P, Marecek S, Varga Z, Klein J, Hu MT, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC; ICEBERG Study Group; RAHAYEL S. Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder. Alzheimers Dement. 2025 Sep;21(9):e70570. doi: 10.1002/alz.70570. PMID: 40970479; PMCID: PMC12447249.

Ayral V, Pastor-Bernier A, Daneault V, Tremblay C, Filiatrault M, Haddad C, Gagnon JF, Postuma RB, Dušek P, Marecek S, Varga Z, Klein JC, Hu MT, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC; ICEBERG Study Group; RAHAYEL S. Association of DTI-ALPS Glymphatic Index With Differential Phenoconversion in Isolated REM Sleep Behavior Disorder: A Multi-Cohort MRI Study. Neurology. 2025 Oct 7;105(7):e214042. doi: 10.1212/WNL.0000000000214042. Epub 2025 Sep 16. PMID: 40956987; PMCID: PMC12456434.

Tremblay C, Pastor-Bernier A, Rheault F, Daneault V, Ayral V, Filiatrault M, Desaulniers L, Vo A, Gagnon JF, Postuma RB, Dusek P, Marecek S, Varga Z, Klein JC, Hu MT, Lehéricy S, Arnulf I, Dodet P, Vidailhet M, Corvol JC; ICEBERG Study Group; RAHAYEL S. Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study. Alzheimers Dement. 2025 Aug;21(8):e70574. doi: 10.1002/alz.70574. PMID: 40791089; PMCID: PMC12340432.

Joza S, Delva A, Tremblay C, Vo A, Filiatrault M, Tweedale M, Gagnon JF, Postuma RB, Dagher A, Klein J, Hu M, Dusek P, Marecek S, Varga Z, Taylor JP, O'Brien JT, Firbank M, Thomas A, Donaghy PC, Lehéricy S; Arnulf I; Vidailhet M, Corvol JC, Iceberg Study Group, Camicioli R, Chertkow H, Lewis S, Matar E, Ehgoetz Martens KA, Churchill L, Sommerauer M, Röttgen S, Borghammer P, Knudsen K, Hansen AK, Arnaldi D, Orso B, Mattioli P, Roccatagliata L, Monchi O, RAHAYEL S. Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder. EBioMedicine. 2025 Jul;117:105753. doi: 10.1016/j.ebiom.2025.105753. Epub 2025 May 29. PMID: 40447483; PMCID: PMC12177146.

RAHAYEL S, Goupil R, Genest DS, Lamarche F, Agharazii M, Ayral V, Tremblay C, Madore F. Lower estimated glomerular filtration rate relates to cognitive impairment and brain alterations. Alzheimers Dement (Amst). 2024 Nov 27;16(4):e70044. doi: 10.1002/dad2.70044. PMID: 39944593; PMCID: PMC11815220.

RAHAYEL S, Postuma R, Baril AA, Misic B, Pelletier A, Soucy JP, Montplaisir J, Dagher A, Gagnon JF. 99mTc-HMPAO SPECT Perfusion Signatures Associated With Clinical Progression in Patients With Isolated REM Sleep Behavior Disorder. Neurology. 2024 Feb;102(4):e208015. doi: 10.1212/WNL.0000000000208015. Epub 2024 Feb 5. PMID: 38315966; PMCID: PMC10890831.

RAHAYEL S, Postuma RB, Gagnon JF. Cholinergic Nucleus 4 Degeneration in Isolated Rapid Eye Movement Sleep Behavior Disorder: One Piece of the Puzzle. Mov Disord. 2023 May;38(5):913-914. doi: 10.1002/mds.29400. PMID: 37303096.

RAHAYEL S, Tremblay C, Vo A, Misic B, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC; ICEBERG Study Group; Gagnon JF, Postuma RB, Montplaisir J, Lewis S, Matar E, Ehgoetz Martens K, Borghammer P, Knudsen K, Hansen AK, Monchi O, Gan-Or Z, Dagher A; Alzheimer’s Disease Neuroimaging Initiative. Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies. Brain. 2023 Aug 1;146(8):3301-3318. doi: 10.1093/brain/awad044. PMID: 36826230; PMCID: PMC10393413.

RAHAYEL S, Tremblay C, Vo A, Zheng YQ, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC; ICEBERG Study Group; Gagnon JF, Postuma RB, Montplaisir J, Lewis S, Matar E, Ehgoetz Martens K, Borghammer P, Knudsen K, Hansen A, Monchi O, Misic B, Dagher A. Brain atrophy in prodromal synucleinopathy is shaped by structural connectivity and gene expression. Brain. 2022 Sep 14;145(9):3162-3178. doi: 10.1093/brain/awac187. PMID: 35594873.

RAHAYEL S, Mišić B, Zheng YQ, Liu ZQ, Abdelgawad A, Abbasi N, Caputo A, Zhang B, Lo A, Kehm V, Kozak M, Yoo HS, Dagher A, Luk KC. Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns. Brain. 2022 Jun 3;145(5):1743-1756. doi: 10.1093/brain/awab440. PMID: 34910119; PMCID: PMC9166565.